HGTV43 is an anti-sense treatment designed to produce T cells that are genetically resistant to HIV infection. HGTV43 is one of a number of so-called 'gene transfer vectors' developed by the biotechnology company Enzo Biochem, Inc.

How gene transfer vectors work

Vectors are used to insert new genetic information into target cells. Enzo Biochem's Stealth Vector technique has achieved insertion of new genetic material into 30% of target cells, in laboratory studies. These cells, genetically engineered to provide new biological functions, can then be transferred to people with diseases such as with HIV.

The company claim that the Stealth Vector will not trigger an immune reaction in humans. See Gene therapy in Anti-HIV therapy: Ways of attacking HIV for further information on these approaches.

How HGTV43 works

HGTV43 works by 'turning off' the genes which HIV needs to grow and reproduce in human cells. Engineered genes are inserted directly into cells to regulate the function of the genes essential for HIV replication. These genetically modified CD4 cells are then transferred back to the individual. The theory is that these individuals will thus have a pool of fully functioning CD4 cells immune to HIV infection.